Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/92397
DC FieldValueLanguage
dc.contributor.authorPinho, Sónia-
dc.contributor.authorMacedo, Maria H-
dc.contributor.authorRebelo, Catarina Araujo Gomes-
dc.contributor.authorSarmento, Bruno-
dc.contributor.authorFerreira, Lino-
dc.date.accessioned2021-01-04T11:47:18Z-
dc.date.available2021-01-04T11:47:18Z-
dc.date.issued2018-
dc.identifier.issn13596446pt
dc.identifier.urihttps://hdl.handle.net/10316/92397-
dc.description.abstractModulation of endogenous adult stem cell niches represents a promising strategy for regeneration of tissues and to correct cell abnormalities, including cancer. Recent advances show the possibility to target endogenous stem cells or their progenies by using nanoparticles conjugated with specific biomolecules. In addition, the targeting of the stem cell niche can be accomplished by using stem cells loaded with nanoparticles. This review examines principles for the targeting of endogenous stem cells as well as factors for the modulation of stem cells.pt
dc.description.sponsorshipThis work was financed by FEDER - Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020 - Operational Programme for Competitiveness and Internationalisation (POCI), Portugal 2020, and by Portuguese funds through FCT - Fundação para a Ciência e a Tecnologia/ Ministério da Ciência, Tecnologia e Inovação in the framework of the projects "Institute for Research 15 and Innovation in Health Sciences" (POCI-01-0145-FEDER-007274 to BS); EC (ERC project nº 307384, “Nanotrigger” and ERA-Chair project nº 669088, ERA@UC, both to LF). SP, MHM and CR would like to thank to Fundação para a Ciência e a Tecnologia (FCT), Portugal, for financial support (SFRH/BPD/96048/2013; SFRH/BD/131587/2017; SFRH/BD/52337/2013).-
dc.language.isoengpt
dc.publisherElsevierpt
dc.rightsopenAccesspt
dc.subject.meshAnimalspt
dc.subject.meshHumanspt
dc.subject.meshNeoplasmspt
dc.subject.meshNanoparticlespt
dc.subject.meshStem Cellspt
dc.titleStem cells as vehicles and targets of nanoparticlespt
dc.typearticle-
degois.publication.firstPage1071-1078pt
degois.publication.lastPage1078pt
degois.publication.issue5pt
degois.publication.titleDrug Discovery Todaypt
dc.peerreviewedyespt
dc.identifier.doi10.1016/j.drudis.2018.01.030pt
degois.publication.volume23pt
dc.date.embargo2018-01-01*
uc.date.periodoEmbargo0pt
item.languageiso639-1en-
item.fulltextCom Texto completo-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypearticle-
item.cerifentitytypePublications-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.orcid0000-0001-8985-9302-
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais
Files in This Item:
File Description SizeFormat
Pinho et al. Drug Discovery.pdf1.72 MBAdobe PDFView/Open
Show simple item record

Google ScholarTM

Check

Altmetric

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.